Vinpocetine
is a medication
used throughout the world to treat brain
aging. It's now available to Americans,
either as an individual supplement or as
part of the Foundation's Cognitex
formulation. The scientific literature
provides persuasive evidence that this
plant extract can improve memory and
cognitive function. By William Faloon
Vinpocetine,
a pharmaceutical extraction from the
periwinkle plant, has become a popular
"smart drug" that Americans
import from Europe for personal use. A
recent ruling in Federal court makes
vinpocetine legally available in the
United States as a low-cost dietary
supplement.
Vinpocetine is now sold in 5-mg
tablets, and has been added as well to
the new Cognitex
formula.
Vinpocetine functions via several
important mechanisms to correct multiple
known causes of brain aging. It is well-established
that normal aging results in a reduction
of blood flow to the brain and a decrease
in the metabolic activity of brain cells.
The biological actions of vinpocetine
initially showed that it enhances
circulation and oxygen utilization in the
brain, increases tolerance of the brain
toward diminished blood flow, and
inhibits abnormal platelet aggregation
that can interfere with circulation or
cause a stroke.
More recent studies demonstrate that
vinpocetine offers significant and direct
protection against neurological damage
caused by aging. The molecular evidence
indicates that the neuroprotective action
of vinpocetine is related to its ability
to maintain brain cell electrical
conductivity and to protect against
damage caused by excessive intracellular
release of calcium. Vinpocetine enhances
cyclic GMP levels in the vascular smooth
muscle, leading to reduced resistance of
cerebral vessels and increased cerebral
blood flow.
It is interesting to note that Viagra,
the widely publicized sex drug, and
vinpocetine both work in the same way to
improve blood flow. Vinpocetine's
improvement in blood flow is specific to
the brain, but like Viagra, vinpocetine
possesses a mechanism that improves blood
flow by inhibiting a phosphodiesterase
enzyme that degrades cyclic GMP. The
degradation of cyclic GMP causes arterial
constriction and reduced blood flow. By
inhibiting a phosphodiesterase enzyme,
vinpocetine increases blood flow to the
brain just as Viagra increases blood flow
to the genitals.
In a double-blind clinical trial-that
is, a medical study in which neither the
subject nor the persons administering the
treatment know which treatment a subject
is receiving-vinpocetine was shown to
effect significant improvement in elderly
patients with chronic cerebral
dysfunction. Forty-two patients received
10 mg of vinpocetine three times a day
for 30 days, then 5 mg three times a day
for 60 days. Placebo tablets were given
to another 42 patients for the 90-day
trial period. Patients on vinpocetine
scored consistently better in all
evaluations, including measurements on
the Clinical Global Impression (CGI)
scale, the Sandoz Clinical Assessment
Geriatric (SCAG) scale, and the Mini-Mental
Status Questionnaire (MMSQ). There were
no serious side effects related to the
treatment drug.
In another double-blind study, 22
elderly patients with central nervous
system degenerative disorders were
treated with vinpocetine or placebo.
Patients received 10 mg of vinpocetine
three times a day for 30 days, then 5 mg
three times a day for 60 days. Another 18
elderly patients were given matching
placebo tablets. Vinpocetine-treated
patients scored consistently better in
all evaluations on the tests noted above.
According to CGI assessments, the
severity of illness decreased in 73
percent of the patients in the
vinpocetine group at day 30 and 77
percent at day 90, and improvement was
seen in 77 percent and 87 percent of the
patients at days 30 and 90, respectively.
Patients also showed statistically
significant improvement for all SCAG
items but one, at days 30 and 90. The
physician rated the improvement in 59
percent of the vinpocetine-treated
patients as good to excellent. Again,
there were no serious side effects.
The effect of vinpocetine on memory
functions was studied in 50 patients with
disturbances of cerebral circulation.
Improvement of cerebral circulation was
observed after intravenous and oral
administration of vinpocetine. Blood flow
was most markedly increased in the gray
matter of the brain. Improvement of
memory capacity evaluated by
psychological tests was recorded after
one month of vinpocetine treatment.
Longer-term use was associated with
alleviation or complete disappearance of
symptoms of neurological deficit. No side
effects attributable to the drug were
observed. The doctors stated that
vinpocetine is indicated in the treatment
of ischemic disorders of cerebral
circulation-that is, a deficiency of
blood, usually due to a constriction or
partial obstruction of a blood vessel-particularly
in chronic vascular insufficiency.
Vinpocetine's safety and efficacy were
demonstrated in a study of infants who
suffered severe brain damage caused by
birth trauma. Vinpocetine caused a
significant reduction or disappearance of
seizures, and the vinpocetine group also
showed a decrease of intracranial
hypertension and normalization of the
psychomotor development.
In a study to ascertain how this
compound boosts cognition in rats,
vinpocetine produced a significant
increase in the firing rate of neurons.
The scientists noted that the dose of
vinpocetine used to increase electrical
firing corresponded to the dose range
that produced memory- enhancing effects.
These results provided direct
electrophysiological evidence that
vinpocetine increases the activity of
ascending noradrenergic pathways, and
that this effect may be related to the
cognitive-enhancing characteristics of
the compound.
Life Extension readers learned
about the damaging effects of glutamate-induced
excitotoxicity earlier this year. A
vitamin B12 metabolite called
methylcobalamin has been shown to
specifically protect against this type of
neuronal injury. Vinpocetine also has
been documented to partially protect
against excitotoxicity induced by a wide
range of glutamate related neurotoxins.
The benefits of vinpocetine are not
restricted to the brain. One study showed
beneficial effects in protecting the
retina against the hepatitis B virus.
While hepatitis viruses primarily affect
the liver, most people don't know that
these viruses can also infect the heart
muscle, retina and other parts of the
body.
Another study showed that vinpocetine
administered to rats inhibited the
development of gastric lesions induced by
ethanol, indicating its potential value
for humans who drink to excess. And, in
fact, vinpocetine is a popular drug used
by alcoholics in Russia to recover from
gastric and neurological ethanol-induced
toxicity.
Space motion sickness has been a
perplexing problem in both the Soviet/Russian
and U.S. manned space programs. Both the
sensory conflict theory (neuronal signal
mismatch) and the cephalad fluid shift
concept explain the mechanism. Whichever
theory is correct, vinpocetine has been
used successfully in offsetting space-motion
sickness in experimental test subjects.
Vinpocetine used to be an expensive
European drug, but is now available as a
low-cost dietary supplement. Health
people need only 15 mg a day of
vinpocetine, the amount contained in the
recommended daily dose of the new
Cognitex formula. Those with neurological
impairment should take 10 mg three times
a day for 30 days, then reduce the dose
to 5 mg three times a day.
Starting about the age of 30, we
typically experience a progressive
decline in cognitive function. By the
time we're in our 60s or 70s, one can
expect severe neurological impairment.
The Foundation has sought out cerebral
anti-aging compounds for two decades now,
and has found several thousand scientific
studies that show brain aging can
be slowed, and impairment can be
reversed.
The recent availability of supplements
like vinpocetine, that used to be
restricted, appear to mitigage many of
the degenerative processes involved in
brain aging.
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